Nanoscale Drug Delivery Systems in Glioblastoma

Zihao Liu; Xiaoshuai Ji; Dong He; Rui Zhang; Qian Liu; Tao Xin

doi:10.1186/s11671-022-03668-6

Nanoscale Drug Delivery Systems in Glioblastoma

Nanoscale Res Lett. 2022 Feb 16;17(1):27. doi: 10.1186/s11671-022-03668-6.

Authors

Zihao Liu¹, Xiaoshuai Ji², Dong He¹, Rui Zhang¹, Qian Liu³, Tao Xin^{4

5

6}

Affiliations

¹ Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China.
² Department of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250014, China.
³ Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. cardioqian@sdu.edu.cn.
⁴ Department of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250014, China. finnick@mail.sdu.edu.cn.
⁵ Department of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Medicine and Health Key Laboratory of Neurosurgery, Jinan, 250014, China. finnick@mail.sdu.edu.cn.
⁶ Department of Neurosurgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang Jiangxi, 330006, China. finnick@mail.sdu.edu.cn.

Abstract

Glioblastoma is the most aggressive cerebral tumor in adults. However, the current pharmaceuticals in GBM treatment are mainly restricted to few chemotherapeutic drugs and have limited efficacy. Therefore, various nanoscale biomaterials that possess distinct structure and unique property were constructed as vehicles to precisely deliver molecules with potential therapeutic effect. In this review, nanoparticle drug delivery systems including CNTs, GBNs, C-dots, MOFs, Liposomes, MSNs, GNPs, PMs, Dendrimers and Nanogel were exemplified. The advantages and disadvantages of these nanoparticles in GBM treatment were illustrated.

Keywords: Biomaterials; Drug delivery systems; Glioblastoma; Nanoparticles.

Publication types

Review

Abstract

Publication types

Grants and funding