Intraocular lens (IOL) implantation surgery is quite effective in the treatment of blindness caused by cataracts. However, in clinical applications, IOLs readily form glistening. This phenomenon usually occurs for a period after IOL implantation ranging from a few months to several years. The molecular mechanism of the formation of glistening in IOLs is still inconclusive. Failure to understand and explain the molecular mechanism of glistening formation greatly hinders the design and application of new glistening-free IOL materials. Here, in this study, we use molecular dynamics simulation methods to conduct in-depth research on the molecular mechanism of the glistening formation of IOLs, aiming to provide a possible molecular mechanism of glistening. Furthermore, based on this molecular mechanism, we propose a novel strategy of a glistening-free material based on a composite design method to reasonably copolymerize several types of molecules or functional groups, so that the glistening phenomenon can be effectively eliminated. The possible molecular mechanism of glistening formation proposed in this research can offer a solid theoretical basis and guidance for the subsequent construction of glistening-free IOL materials.