Dimethyl fumarate ameliorates graft-versus-host disease by inhibiting T-cell metabolism and immune responses through a reactive oxygen species-dependent mechanism

Br J Haematol. 2022 Jun;197(6):e78-e82. doi: 10.1111/bjh.18082. Epub 2022 Feb 15.

Affiliations

¹ Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.
² Core Center of Research Apparatus, Jichi Medical University, Tochigi, Japan.
³ Department of Biochemistry, Jichi Medical University, Tochigi, Japan.

PMID: 35170051
DOI: 10.1111/bjh.18082

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Dimethyl Fumarate* / pharmacology
Dimethyl Fumarate* / therapeutic use
Graft vs Host Disease* / drug therapy
Humans
Immunity
Reactive Oxygen Species / metabolism
T-Lymphocytes / metabolism

Substances

Reactive Oxygen Species
Dimethyl Fumarate