Interplay between stress and immunity triggers herpes zoster infection in COVID-19 patients: a review

Can J Microbiol. 2022 May;68(5):303-314. doi: 10.1139/cjm-2021-0242. Epub 2022 Feb 15.

Abstract

Coronavirus disease 2019 (COVID-19) is a potential health threat in the highly mobile society of the world. There are also concerns regarding the occurrence of co-infections occurring in COVID-19 patients. Herpes zoster (HZ) is currently being reported as a co-infection in COVID-19 patients. It is a varicella-zoster virus induced viral infection affecting older and immunocompromised individuals. Reactivation of HZ infection in COVID-19 patients are emerging and the mechanism of reactivation is still unknown. The most convincing argument is that increased psychological and immunological stress leads to HZ in COVID-19 patients; this review justifies this argument.

Keywords: COVID-19; herpes zoster; herpès zoster; immunity; immunité; stress; varicella-zoster virus; virus varicelle-zona.

Publication types

  • Review

MeSH terms

  • COVID-19*
  • Herpes Zoster* / complications
  • Herpes Zoster* / epidemiology
  • Herpesvirus 3, Human
  • Humans
  • Immunocompromised Host