Cancer Immunoediting: Elimination, Equilibrium, and Immune Escape in Solid Tumors

Jacek R Wilczyński; Marek Nowak

doi:10.1007/978-3-030-91311-3_1

Cancer Immunoediting: Elimination, Equilibrium, and Immune Escape in Solid Tumors

Exp Suppl. 2022:113:1-57. doi: 10.1007/978-3-030-91311-3_1.

Authors

Jacek R Wilczyński¹, Marek Nowak^{2

3}

Affiliations

¹ Department of Gynecologic Surgery and Gynecologic Oncology, Medical University of Lodz, Lodz, Poland. jrwil@post.pl.
² Department of Operative Gynecology and Gynecologic Oncology, Polish Mother's Memorial Hospital-Research Institute, Lodz, Poland.
³ Department of Operative and Endoscopic Gynecology, Medical University of Lodz, Lodz, Poland.

PMID: 35165859
DOI: 10.1007/978-3-030-91311-3_1

Abstract

Emphasizing the dynamic processes between cancer and host immune system, the initially discovered concept of cancer immunosurveillance has been replaced by the current concept of cancer immunoediting consisting of three phases: elimination, equilibrium, and escape. Solid tumors composed of both cancer and host stromal cells are an example how the three phases of cancer immunoediting functionally evolve and how tumor shaped by the host immune system gets finally resistant phenotype. The elimination, equilibrium, and escape have been described in this chapter in details, including the role of immune surveillance, cancer dormancy, disruption of the antigen-presenting machinery, tumor-infiltrating immune cells, resistance to apoptosis, as well as the function of tumor stroma, microvesicles, exosomes, and inflammation.

Keywords: Cancer dormancy; Cancer escape mechanisms; Cancer immunoediting; Immunosurveillance.

MeSH terms

Humans
Immunologic Surveillance
Inflammation
Neoplasms* / genetics
Tumor Escape* / genetics