Antibacterial and Chemical Characterization of Silica-Quercetin-PEG Hybrid Materials Synthesized by Sol-Gel Route

Molecules. 2022 Feb 1;27(3):979. doi: 10.3390/molecules27030979.

Abstract

This paper aims to synthesize, via the sol-gel method, a biomaterial usable in the medical field. Here, the silica-PEG-quercetin system was evaluated in relation to the different concentrations of PEG (0, 6, 12, 24, 50 wt%) and quercetin (0, 5, 10, 15 wt%), respectively. In addition, Fourier Transform-Infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), and Kirby-Bauer analyses were performed. FT-IR was used to evaluate the hybrid formation and the influence of both PEG and Quercetin in the hybrid synthesized materials, SEM was used to evaluate the morphological properties, while the Kirby-Bauer test was used to understand the ability of the materials to inhibit the growth of the assayed bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, and Staphylococcus aureus).

Keywords: FT-IR; SEM; anti-bacterial properties; hybrids materials; sol–gel method.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / classification
  • Bacteria / drug effects*
  • Biocompatible Materials / chemistry
  • Microbial Sensitivity Tests
  • Microscopy, Electron, Scanning
  • Polyethylene Glycols / chemistry*
  • Quercetin / chemistry*
  • Silicon Dioxide / chemistry*
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Anti-Bacterial Agents
  • Biocompatible Materials
  • Polyethylene Glycols
  • Silicon Dioxide
  • Quercetin