Effect of Carbohydrate-Enriched Drink Compared to Fasting on Hemodynamics in Healthy Volunteers. A Randomized Trial

Jakub Kukliński; Karol P Steckiewicz; Sebastian P Piwowarczyk; Mateusz J Kreczko; Aleksander Aszkiełowicz; Radosław Owczuk

doi:10.3390/jcm11030825

Effect of Carbohydrate-Enriched Drink Compared to Fasting on Hemodynamics in Healthy Volunteers. A Randomized Trial

J Clin Med. 2022 Feb 4;11(3):825. doi: 10.3390/jcm11030825.

Authors

Jakub Kukliński¹, Karol P Steckiewicz¹, Sebastian P Piwowarczyk², Mateusz J Kreczko¹, Aleksander Aszkiełowicz¹, Radosław Owczuk¹

Affiliations

¹ Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdańsk, Poland.
² Students Scientific Society, Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdańsk, Poland.

Abstract

Fasting prior to surgery can cause dehydration and alter hemodynamics. This study aimed to determine the impact of a carbohydrate-enriched drink (Nutricia^TM Pre-op^®) on selected hemodynamical parameters, measured in a non-invasive manner. We enrolled 100 healthy volunteers and measured their weight, height, systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), thoracic fluid content (TFC), thoracic fluid index (TFCI), stroke volume (SV), stroke volume variation (SVV), stroke index (SI), cardiac output (CO), cardiac index (CI), heather index (HI), systolic time ration (STR), systemic time ratio index (STRI), systemic vascular resistance (SVR), and systemic vascular resistance index (SVRI) by a Niccomo™ device, implementing the impedance cardiography (ICG) method. Measurements were performed at the beginning of the study, and after 10 h and 12 h. We randomly allocated participants to the control group and the pre-op group. The pre-op group received 400 mL of Nutricia™ preOp^®, as suggested in the ERAS guidelines, within 10 h of the study. Student's t-test or the Mann-Whitney U test were used to compare the two groups, and p < 0.05 was considered significant. We did not observe any changes in hemodynamical parameters, blood pressure, and heart rate between the groups. We have proven that carbohydrate-enriched drink administration did not have a significant impact on the hemodynamical parameters of healthy volunteers.

Keywords: NICCOMO; cardiac index (CI); enhanced recovery after surgery (ERAS); fasting; hemodynamics; impedance cardiography (ICG); perioperative patient management; pre-op; systemic vascular resistance index (SVRI).