Endocrine Fibroblast Growth Factors in Relation to Stress Signaling

Makoto Shimizu; Ryuichiro Sato

doi:10.3390/cells11030505

Endocrine Fibroblast Growth Factors in Relation to Stress Signaling

Cells. 2022 Feb 1;11(3):505. doi: 10.3390/cells11030505.

Authors

Makoto Shimizu¹, Ryuichiro Sato^{1

2}

Affiliations

¹ Nutri-Life Science Laboratory, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan.
² Food Biochemistry Laboratory, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan.

Abstract

Fibroblast growth factors (FGFs) play important roles in various growth signaling processes, including proliferation, development, and differentiation. Endocrine FGFs, i.e., atypical FGFs, including FGF15/19, FGF21, and FGF23, function as endocrine hormones that regulate energy metabolism. Nutritional status is known to regulate the expression of endocrine FGFs through nuclear hormone receptors. The increased expression of endocrine FGFs regulates energy metabolism processes, such as fatty acid metabolism and glucose metabolism. Recently, a relationship was found between the FGF19 subfamily and stress signaling during stresses such as endoplasmic reticulum stress and oxidative stress. This review focuses on endocrine FGFs and the recent progress in FGF studies in relation to stress signaling. In addition, the relevance of the stress-FGF pathway to disease and human health is discussed.

Keywords: ER stress; FGF15/19; FGF21; FGF23; endocrine FGFs; oxidative stress; stress signaling.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Endocrine System* / metabolism
Fibroblast Growth Factors* / metabolism
Humans
Lipid Metabolism
Oxidative Stress
Signal Transduction

Substances

Fibroblast Growth Factors