Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait

Helen Pantazopoulos; Mame-Kany Diop; Andrée-Anne Grosset; Frédérique Rouleau-Gagné; Afnan Al-Saleh; Teodora Boblea; Dominique Trudel

doi:10.3390/cancers14030820

Intraductal Carcinoma of the Prostate as a Cause of Prostate Cancer Metastasis: A Molecular Portrait

Cancers (Basel). 2022 Feb 6;14(3):820. doi: 10.3390/cancers14030820.

Authors

Helen Pantazopoulos^{1

2

3}, Mame-Kany Diop^{1

2

3}, Andrée-Anne Grosset^{1

2

3}, Frédérique Rouleau-Gagné^{1

2

3}, Afnan Al-Saleh^{1

2

3}, Teodora Boblea^{1

2}, Dominique Trudel^{1

2

3

4}

Affiliations

¹ Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 Saint-Denis, Montreal, QC H2X 0A9, Canada.
² Institut du Cancer de Montréal, 900 Saint-Denis, Montreal, QC H2X 0A9, Canada.
³ Department of Pathology and Cellular Biology, Université de Montréal, 2900 Boulevard Édouard-Montpetit, Montreal, QC H3T 1J4, Canada.
⁴ Department of Pathology, Centre Hospitalier de l'Université de Montréal (CHUM), 1051 Sanguinet, Montreal, QC H2X 0C1, Canada.

Abstract

Intraductal carcinoma of the prostate (IDC-P) is one of the most aggressive types of prostate cancer (PCa). IDC-P is identified in approximately 20% of PCa patients and is associated with recurrence, metastasis, and PCa-specific death. The main feature of this histological variant is the colonization of benign glands by PCa cells. Although IDC-P is a well-recognized independent parameter for metastasis, mechanisms by which IDC-P cells can spread and colonize other tissues are not fully known. In this review, we discuss the molecular portraits of IDC-P determined by immunohistochemistry and genomic approaches and highlight the areas in which more research is needed.

Keywords: Raman micro-spectroscopy; biomarkers; genomic; immunohistochemistry; intraductal carcinoma of the prostate (IDC-P); metastasis.

Publication types

Review