Parallel locomotor control strategies in mice and flies

Abstract

Our understanding of the neural basis of locomotor behavior can be informed by careful quantification of animal movement. Classical descriptions of legged locomotion have defined discrete locomotor gaits, characterized by distinct patterns of limb movement. Recent technical advances have enabled increasingly detailed characterization of limb kinematics across many species, imposing tighter constraints on neural control. Here, we highlight striking similarities between coordination patterns observed in two genetic model organisms: the laboratory mouse and Drosophila. Both species exhibit continuously-variable coordination patterns with similar low-dimensional structure, suggesting shared principles for limb coordination and descending neural control.