The Role of Sleep-Disordered Breathing Symptoms in Neurocognitive Function Among Youth With Sickle Cell Disease

Elise M Turner; M S Natalie Koskela-Staples; B S Corinne Evans; L Vandy Black; Shelley C Heaton; David A Fedele

doi:10.1080/87565641.2022.2038601

The Role of Sleep-Disordered Breathing Symptoms in Neurocognitive Function Among Youth With Sickle Cell Disease

Dev Neuropsychol. 2022 Mar-Apr;47(2):93-104. doi: 10.1080/87565641.2022.2038601. Epub 2022 Feb 14.

Authors

Elise M Turner¹, M S Natalie Koskela-Staples¹, B S Corinne Evans¹, L Vandy Black², Shelley C Heaton¹, David A Fedele¹

Affiliations

¹ Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida, USA.
² Division of Pediatric Hematology and Oncology, College of Medicine, University of Florida, Gainesville, Florida, USA.

PMID: 35157528
DOI: 10.1080/87565641.2022.2038601

Abstract

Objective: To examine associations between sleep-disordered breathing (SDB) and executive/attentional function in pediatric sickle cell disease (SCD).

Methods: Sixty youth with SCD ages 8-18 years and caregivers completed the Pediatric Sleep Questionnaire (PSQ), Delis Kaplan Executive Function System Trail Making Test (DKEFS TMT), Psychomotor Vigilance Test (PVT), and the Behavior Rating Inventory Of Executive Function, Second Edition (BRIEF-2) Parent Report.

Results: The PSQ significantly predicted the BRIEF-2 Parent Report, F(1, 58) = 44.64, p < .001, R² = 0.44, f² = 0.77.

Conclusions: Sleep-disordered breathing symptoms may predict informant-rated executive dysfunction in pediatric SCD, but not performance-based executive function.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Anemia, Sickle Cell* / complications
Anemia, Sickle Cell* / psychology
Child
Cognitive Dysfunction* / diagnosis
Cognitive Dysfunction* / etiology
Executive Function
Humans
Sleep Apnea Syndromes* / diagnosis
Sleep Apnea Syndromes* / psychology
Surveys and Questionnaires