Review of LINC00707: A Novel LncRNA and Promising Biomarker for Human Diseases

Qinfan Yao; Zheng Li; Dajin Chen

doi:10.3389/fcell.2022.813963

Review of LINC00707: A Novel LncRNA and Promising Biomarker for Human Diseases

Front Cell Dev Biol. 2022 Jan 26:10:813963. doi: 10.3389/fcell.2022.813963. eCollection 2022.

Authors

Qinfan Yao^{1

2

3

4}, Zheng Li^{1

2

3

4}, Dajin Chen^{1

2

3

4}

Affiliations

¹ Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
² Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China.
³ National Key Clinical Department of Kidney Diseases, Institute of Nephrology, Zhejiang University, Hangzhou, China.
⁴ Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.

Abstract

Long noncoding RNAs (lncRNAs) are a major type of noncoding RNA greater than 200 nucleotides in length involved in important regulatory processes. Abnormal expression of certain lncRNAs contributes to the pathogenesis of multiple diseases, including cancers. The lncRNA LINC00707 is located on chromosome 10p14 and is abnormally expressed in numerous disease types, and particularly in several types of cancer. High LINC00707 levels mediate a series of biological functions, including cell proliferation, apoptosis, metastasis, invasion, cell cycle arrest, inflammation, and even osteogenic differentiation. In this review, we discuss the main functions and underlying mechanisms of LINC00707 in different diseases and describe promising applications of LINC00707 in clinical settings.

Keywords: LINC00707; clinical characteristic; function; lncRNA; mechanism.

Publication types

Review