Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression

Zhuang Chen; Rui Yuan; Shengyun Hu; Weitang Yuan; Zhenqiang Sun

doi:10.3389/fimmu.2022.817942

Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression

Front Immunol. 2022 Jan 27:13:817942. doi: 10.3389/fimmu.2022.817942. eCollection 2022.

Authors

Zhuang Chen¹, Rui Yuan¹, Shengyun Hu¹, Weitang Yuan¹, Zhenqiang Sun¹

Affiliation

¹ Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Abstract

Tumor immunity is involved in malignant tumor progression. Myeloid-derived suppressor cells (MDSCs) play an irreplaceable role in tumor immunity. MDSCs are composed of immature myeloid cells and exhibit obvious immunomodulatory functions. Exosomes released by MDSCs (MDSCs-Exos) have similar effects to parental MDSCs in regulating tumor immunity. In this review, we provided a comprehensive description of the characteristics, functions and mechanisms of exosomes. We analyzed the immunosuppressive, angiogenesis and metastatic effects of MDSCs-Exos in different tumors through multiple perspectives. Immunotherapy targeting MDSCs-Exos has demonstrated great potential in cancers and non-cancerous diseases.

Keywords: cancer; exosome; immune escape; myeloid-derived suppressor cells; tumor immunity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Exosomes / immunology
Humans
Immunotherapy
Myeloid-Derived Suppressor Cells / immunology*
Myeloid-Derived Suppressor Cells / pathology
Neoplasms / immunology*
Neoplasms / pathology
Neoplasms / therapy
Tumor Microenvironment / immunology