Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease, which is one of the major complications in COVID-19 patients. Dysregulation of the immune system and imbalances in cytokine release and immune cell activation are involved in SARS-CoV-2 infection. Here, the inflammatory, antigen, and auto-immune profile of patients presenting COVID-19-associated severe ARDS has been analyzed using functional proteomics approaches. Both, innate and humoral responses have been characterized through acute-phase protein network and auto-antibody signature. Severity and sepsis by SARS-CoV-2 emerged to be correlated with auto-immune profiles of patients and define their clinical progression, which could provide novel perspectives in therapeutics development and biomarkers of COVID-19 patients. Humoral response in COVID-19 patients' profile separates with significant differences patients with or without ARDS. Furthermore, we found that this profile can be correlated with COVID-19 severity and results more common in elderly patients.
Keywords: ARDS; COVID-19; SARS-CoV-2; acute-phase proteins; antigen; auto-antibodies; microarrays; proteomics.
Copyright © 2022 Juanes-Velasco, Landeira-Viñuela, García-Vaquero, Lecrevisse, Herrero, Ferruelo, Góngora, Corrales, Rivas, Lorente, Hernández and Fuentes.