Objective: To compare the curative effect of Tiaoshen acupuncture combined with artificial tears and artificial tears alone for dry eye syndrome with yin deficiency of liver and kidney.
Methods: A total of 70 patients of dry eye syndrome with yin deficiency of liver and kidney were randomized into an acupuncture combined with medication group (35 cases, 2 cases dropped off) and a medication group (35 cases, 3 cases dropped off). In the medication group, 0.1% sodium hyaluronate eye drop was applied, 3 times a day, 1 drop each time. On the basis of the treatment as the medication group, Tiaoshen acupuncture was applied at Shenting (GV 24), Shenmen (HT 7), Benshen (GB 13), Taixi (KI 3), Taichong (LR 3), Guangming (GB 37), Fengchi (GB 20), Tongziliao (GB 1), Yuyao (EX-HN 4) in the acupuncture combined with medication group, Tongziliao (GB 1) and Yuyao (EX-HN 4) were connect with electroacupuncture, the needles were retained for 30 min, once a day, 6 times a week. Both groups were treated for 2 weeks. Before and after treatment, the clinical symptom score, SchirmerⅠtest (SⅠT), break-up time (BUT), corneal fluorescein staining (FL) score and Hamilton anxiety scale (HAMA) score were observed in the two groups, and the clinical efficacy was compared in the two groups.
Results: Compared before treatment, the clinical symptom scores, corneal FL and HAMA scores were decreased (P<0.05), the levels of SⅠT and BUT were increased after treatment in the two groups (P<0.05). After the treatment, the clinical symptom score, FL and HAMA scores in the acupuncture combined with medication group were lower than the medication group (P<0.05), the levels of SⅠT and BUT in the acupuncture combined with medication group were higher than the medication group (P<0.05). The total effective rate in the acupuncture combined with medication group was 90.9% (30/33), which was higher than 71.9% (23/32) in the medication group (P<0.05).
Conclusion: Tiaoshen acupuncture combined with artificial tears could promote the secretion of tears for patients of dry eye syndrome with yin deficiency of liver and kidney, repair corneal defect and prolong tear film break-up time, and alleviate anxiety state, its curative effect is better than simple artificial tears.
目的：比较调神法针刺结合人工泪液与单纯人工泪液治疗肝肾阴虚型干眼症的疗效。方法：将70例肝肾阴虚型干眼症患者随机分为针药组（35例，脱落2例）和药物组（35例，脱落3例）。药物组采用0.1%玻璃酸钠滴眼液治疗，每日3次，每次1滴；针药组在药物组治疗基础上予调神法针刺，穴取神庭、神门、本神、太溪、太冲、光明、风池、瞳子髎、鱼腰，瞳子髎与鱼腰接电针，留针30 min，每日1次，每周治疗6次，两组均治疗2周。观察两组患者治疗前后临床症状积分、泪液分泌试验（SⅠT）、泪膜破裂时间（BUT）、角膜荧光素染色（FL）评分、汉密尔顿焦虑量表（HAMA）评分，并比较两组临床疗效。结果：两组治疗后临床症状积分及角膜FL、HAMA评分均较治疗前降低（P<0.05），SⅠT、BUT均较治疗前升高（P<0.05）。针药组治疗后临床症状积分及角膜FL、HAMA评分均低于药物组（P<0.05），针药组治疗后SⅠT、BUT优于药物组（P<0.05）。针药组总有效率为90.9%（30/33），高于药物组的71.9%（23/32）。结论：调神法针刺结合人工泪液治疗肝肾阴虚型干眼症可以促进患者泪液分泌，修复角膜缺损并延长泪膜破裂时间，同时缓解患者焦虑状态，疗效优于单纯人工泪液治疗。.
Keywords: SchirmerⅠtest (SⅠT); Tiaoshen method; acupuncture; break-up time (BUT); dry eye syndrome, yin deficiency of liver and kidney; randomized controlled trial (RCT).