Facklamia hominis pyelonephritis in a pediatric patient: first case report and review of the literature

Ann Clin Microbiol Antimicrob. 2022 Feb 12;21(1):4. doi: 10.1186/s12941-022-00497-4.

Abstract

Background: Pyelonephritis is one of the most serious bacterial illnesses during childhood. Gram-negative organisms account for up to 90% of the cases. Gram-positive bacteria are uncommon causes of urinary tract infections, and only a few cases caused by Facklamia hominis have been reported in the literature.

Case presentation: A five-year-old girl with tracheostomy and gastrostomy and past medical history of congenital lymphangioma presented with a two-week history of with intermittent fever, frequent urination, and vesical tenesmus. Diagnosis of pyelonephritis was made. Urine culture reported colonies with alpha-hemolysis in blood agar at 48-h of incubation and Facklamia hominis was identified by MALDI-TOF. The patient was successfully treated with gentamicin.

Conclusions: This is the first reported case of pyelonephritis by Facklamia hominis in a child, and the second involving infection in a pediatric patient. Although this pathogen is uncommon, current treatment of F. hominis is a challenge for physicians. This case illustrates the requirement to standardize identification and treatment of care to avoid treatment failure and antimicrobial resistance.

Keywords: Child; Children; Emerging pathogen; Facklamia hominis; Pediatric; Urinary tract infection.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aerococcaceae / isolation & purification*
  • Anti-Bacterial Agents / therapeutic use
  • Child, Preschool
  • Female
  • Fever / etiology
  • Gentamicins / therapeutic use
  • Humans
  • Pyelonephritis / diagnosis*
  • Pyelonephritis / drug therapy
  • Treatment Outcome
  • Urinary Tract Infections / diagnosis*
  • Urinary Tract Infections / drug therapy

Substances

  • Anti-Bacterial Agents
  • Gentamicins

Supplementary concepts

  • Facklamia hominis