Phenylpropanoids from Brachybotrys paridiformis Maxim. ex Oliv. and their anti-HBV activities

Si-Tong Wu; Yi-Xiao Wang; Bai-Hong Yu; Chun-Liu Ma; He-Qin Qiu; Guang-Shu Wang

doi:10.1016/j.phytochem.2022.113114

Phenylpropanoids from Brachybotrys paridiformis Maxim. ex Oliv. and their anti-HBV activities

Phytochemistry. 2022 May:197:113114. doi: 10.1016/j.phytochem.2022.113114. Epub 2022 Feb 8.

Authors

Si-Tong Wu¹, Yi-Xiao Wang¹, Bai-Hong Yu¹, Chun-Liu Ma¹, He-Qin Qiu¹, Guang-Shu Wang²

Affiliations

¹ School of Pharmaceutical Sciences, Jilin University, Changchun, 130021, People's Republic of China.
² School of Pharmaceutical Sciences, Jilin University, Changchun, 130021, People's Republic of China. Electronic address: wgs@jlu.edu.cn.

PMID: 35149306
DOI: 10.1016/j.phytochem.2022.113114

Abstract

Using chemical and spectroscopic data, this study on Brachybotrys paridiformis Maxim. ex Oliv. identified four undescribed phenylpropanoids, brachin A-C and brachoside A, together with nine other known compounds. The isolated compounds were tested for anti-hepatitis B virus activities in the HepG2.2.15 cell line. Among them, caffeic anhydride showed the most potent activity.

Keywords: Anti-HBV activity; Boraginaceae; Brachybotrys paridiformis; Phenylpropanoids.

MeSH terms

Antiviral Agents / pharmacology
Boraginaceae*
Hep G2 Cells
Hepatitis B virus*
Humans

Substances

Antiviral Agents