Conventional vs high-frequency ventilation for weaning from total liquid ventilation in lambs

Christophe Morin; Symon Stowe; Charles Alain; Wendy See; Michaël Sage; Charlène Nadeau; Nathalie Samson; Andy Adler; Philippe Micheau; Jean-Paul Praud; Étienne Fortin-Pellerin

doi:10.1016/j.resp.2022.103867

Conventional vs high-frequency ventilation for weaning from total liquid ventilation in lambs

Respir Physiol Neurobiol. 2022 May:299:103867. doi: 10.1016/j.resp.2022.103867. Epub 2022 Feb 8.

Authors

Affiliations

¹ Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
² Department of Computer Engineering, Carleton University, Ottawa, ON, Canada.
³ Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
⁴ Department of Mechanical Engineering, Faculty of Engineering, Université de Sherbrooke, Sherbrooke, QC, Canada.
⁵ Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada; Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
⁶ Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada; Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada. Electronic address: Etienne.fortin-pellerin@usherbrooke.ca.

PMID: 35149225
DOI: 10.1016/j.resp.2022.103867

Abstract

Objective: To compare conventional gas ventilation (GV) and high-frequency oscillatory ventilation (HFOV) for weaning from total liquid ventilation (TLV).

Methods: Sixteen lambs were anesthetized. After 1 h of TLV with perflubron (PFOB), they were assigned to either GV or HFOV for 2 h. Oxygen requirements, electrical impedance tomography and videofluoroscopic sequences, and respiratory system compliance were recorded.

Results: The lambs under GV needed less oxygen at 20 min following TLV (40 [25, 45] and 83 [63, 98]%, p = 0.001 under GV and HFOV, respectively). During weaning, tidal volume distribution was increased in the nondependent regions in the GV group compared to baseline (p = 0.046). Furthermore, residual PFOB was observed in the most dependent region. No air was detected by fluoroscopy in that region at the end of expiration in the GV group.

Conclusion: GV offers a transient advantage over HFOV with regards to oxygenation for TLV weaning.

Keywords: Electrical impedance tomography; High-frequency oscillatory ventilation; Lamb; Neonate; Total liquid ventilation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
High-Frequency Ventilation* / methods
Liquid Ventilation* / methods
Lung
Oxygen
Pulmonary Gas Exchange
Sheep
Sheep, Domestic

Substances

Oxygen