Recent advances on next generation of polyzwitterion-based nano-vectors for targeted drug delivery

Hongliang Qian; Ke Wang; Mengtong Lv; Changshun Zhao; Hui Wang; Suchen Wen; Dechun Huang; Wei Chen; Yinan Zhong

doi:10.1016/j.jconrel.2022.02.004

Recent advances on next generation of polyzwitterion-based nano-vectors for targeted drug delivery

J Control Release. 2022 Mar:343:492-505. doi: 10.1016/j.jconrel.2022.02.004. Epub 2022 Feb 8.

Authors

Hongliang Qian¹, Ke Wang¹, Mengtong Lv¹, Changshun Zhao¹, Hui Wang¹, Suchen Wen¹, Dechun Huang², Wei Chen³, Yinan Zhong⁴

Affiliations

¹ Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
² Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China; Engineering Research Center for Smart Pharmaceutical Manufacturing Technologies, Ministry of Education, School of Engineering, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpuhdc@cpu.edu.cn.
³ Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China; Engineering Research Center for Smart Pharmaceutical Manufacturing Technologies, Ministry of Education, School of Engineering, China Pharmaceutical University, Nanjing 210009, China. Electronic address: w.chen@cpu.edu.cn.
⁴ Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China. Electronic address: ynzhong@cpu.edu.cn.

PMID: 35149143
DOI: 10.1016/j.jconrel.2022.02.004

Abstract

Poly (ethylene glycol) (PEG)-based nanomedicines are perplexed by the challenges of oxidation damage, immune responses after repeated injections, and limited excretion from the body. As an alternative to PEG, bioinspired zwitterions bearing an identical number of positive and negative ions, exhibit exceptional hydrophilicity, excellent biomimetic nature and chemical malleability, endowing zwitterionic nano-vectors with biocompatibility, non-fouling feature, extended blood circulation and multifunctionality. In this review, we innovatively classify zwitterionic nano-vectors into linear, hyperbranched, crosslinked, and hybrid nanoparticles according to different chemical architectures in rational design of zwitterionic nano-vectors for enhanced drug delivery with an emphasis on zwitterionic engineering innovations as alternatives of PEG-based nanomedicines. Through combination with other nanostrategies, the intelligent zwitterionic nano-vectors can orchestrate stealth and other biological functionalities together to improve the efficacy in the whole journey of drug delivery.

Keywords: Chemical structures; Drug delivery; Extended blood circulation; Protein resistance; Zwitterionic nano-vector.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Drug Delivery Systems*
Hydrophobic and Hydrophilic Interactions
Ions
Nanoparticles*
Polyethylene Glycols

Substances

Ions
Polyethylene Glycols