Employing Visible-Light Photoredox Catalysis in Multicomponent-Multicatalyst Reactions: One-Pot Synthesis of Spiroquinazolin-2-(thi)ones

Zhentao Pan; Xuancheng Yang; Bo Chen; Shuaijun Shi; Tong Liu; Xuqiong Xiao; Linlin Shen; Li Lou; Yongmin Ma

doi:10.1021/acs.joc.1c03151

Employing Visible-Light Photoredox Catalysis in Multicomponent-Multicatalyst Reactions: One-Pot Synthesis of Spiroquinazolin-2-(thi)ones

J Org Chem. 2022 Mar 4;87(5):3596-3604. doi: 10.1021/acs.joc.1c03151. Epub 2022 Feb 11.

Authors

Zhentao Pan¹, Xuancheng Yang¹, Bo Chen¹, Shuaijun Shi¹, Tong Liu¹, Xuqiong Xiao², Linlin Shen³, Li Lou⁴, Yongmin Ma¹

Affiliations

¹ Institute of Advanced Studies and School of Pharmaceutical and Chemical Engineering, Taizhou University, Jiaojiang 318000, Zhejiang, China.
² Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
³ Institute of Advanced Studies and School of Pharmaceutical, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
⁴ Institute of Advanced Studies and School of Pharmaceutical, Fujian University of Traditional Chinese Medicine, 350000 Fujian, China.

PMID: 35147433
DOI: 10.1021/acs.joc.1c03151

Abstract

The multicomponent-multicatalyst reaction ((MC)²R) and visible-light catalysis have emerged as green and powerful strategies for achieving ideal syntheses. Here, we report the first example of a visible-light-induced approach toward spiroquinazolin(thi)ones. This (MC)²R features an eco-friendly energy source and solvent, metal-free catalysts, step- and atom-economy, a relay catalysis strategy, air as green oxidant, mild conditions, and easily accessible starting materials.