Previous research has shown that Stroop interference and reading ability are negatively related, with higher reading skills associated with less interference. A direct link between interference and the speed of inhibition of the task-irrelevant dimension (i.e., word) has been proposed to explain this relationship. If that were the case then it should apply regardless of the format of the Stroop task, that is, whether stimuli are presented simultaneously (multi-item version) or individually (single-item version). Here we examine data from six experiments using single-item and multi-item Stroop tasks and their relationship to reading measures. Our results indicate that reading performance is primarily related to the multi-item version of the Stroop task and not to the single-item version. These findings question the direct link between inhibition and interference as an interpretation of the reading-interference relationship. We argue that cascaded processing of successive items, and the ability to monitor and control this process, is the cognitive mechanism regulating the relationship between reading and interference. Therefore, we propose that the link between Stroop interference and reading is indirect, and their relationship is determined by the efficiency in temporally overlapping processing of adjacent items. (PsycInfo Database Record (c) 2022 APA, all rights reserved).