β-Aminopropionitrile-induced aortic aneurysm and dissection in mice

Hisashi Sawada; Zachary A Beckner; Sohei Ito; Alan Daugherty; Hong S Lu

doi:10.1016/j.jvssci.2021.12.002

β-Aminopropionitrile-induced aortic aneurysm and dissection in mice

JVS Vasc Sci. 2022 Jan 3:3:64-72. doi: 10.1016/j.jvssci.2021.12.002. eCollection 2022.

Authors

Hisashi Sawada^{1

2

3}, Zachary A Beckner^{1

2}, Sohei Ito^{1

2}, Alan Daugherty^{1

2

3}, Hong S Lu^{1

2

3}

Affiliations

¹ Saha Cardiovascular Research Center, University of Kentucky, Lexington, Ky.
² Saha Aortic Center, University of Kentucky, Lexington, Ky.
³ Department of Physiology, University of Kentucky, Lexington, Ky.

Abstract

The mechanistic basis for the formation of aortic aneurysms and dissection needs to be elucidated to facilitate the development of effective medications. β-Aminopropionitrile administration in mice has been used frequently to study the pathologic features and mechanisms of aortic aneurysm and dissection. This mouse model mimics several facets of the pathology of human aortic aneurysms and dissection, although many variables exist in the experimental design and protocols that must be resolved to determine its application to the human disease. In the present brief review, we have introduced the development of this mouse model and provided insights into understanding its pathologic features.

Keywords: Aortic aneurysms; Aortic dissection; Mouse; β-Aminopropionitrile.

Publication types

Review

Abstract

Publication types

Grants and funding