Augmented Renal Clearance: An Under-Recognized Phenomenon Associated With COVID-19

Denise H Rhoney; Ashley B Brooks; Nicholas R Nelson

doi:10.1097/CCE.0000000000000617

Augmented Renal Clearance: An Under-Recognized Phenomenon Associated With COVID-19

Crit Care Explor. 2022 Feb 4;4(2):e0617. doi: 10.1097/CCE.0000000000000617. eCollection 2022 Feb.

Authors

Denise H Rhoney¹, Ashley B Brooks², Nicholas R Nelson³

Affiliations

¹ Division of Practice Advancement and Clinical Education, UNC Eshelman School of Pharmacy, Chapel Hill, NC.
² East Carolina University, Greenville, NC.
³ Department of Pharmacy, Michigan Medicine, Ann Arbor, MI.

Abstract

Augmented renal clearance (ARC) is a phenomenon that has been described mainly in critically ill patients and is characterized by increased creatinine clearance and elimination of renally cleared medications that could place patients at risk of therapeutic failure. The COVID-19 pandemic has led to an overwhelming number of ICU admissions with many reports of the impact of COVID-19 on the kidney. This report aims to increase clinician awareness of, and risk factors for ARC in patients with COVID-19, especially in comparison to other critical illnesses.

Keywords: COVID-19; augmented renal clearance; creatinine clearance; critical care.