Missing sputum samples are common in asthma intervention studies and successful collection at follow-up is related to improvement in clinical outcomes

Laurits Frøssing; Morten Hvidtfeldt; Alexander Silberbrandt; Asger Sverrild; Celeste Porsbjerg

doi:10.1183/23120541.00612-2021

Missing sputum samples are common in asthma intervention studies and successful collection at follow-up is related to improvement in clinical outcomes

ERJ Open Res. 2021 Feb 7;8(1):00612-2021. doi: 10.1183/23120541.00612-2021. eCollection 2022 Jan.

Authors

Laurits Frøssing¹, Morten Hvidtfeldt¹, Alexander Silberbrandt¹, Asger Sverrild¹, Celeste Porsbjerg¹

Affiliation

¹ Respiratory Research Unit, Dept of Respiratory Medicine, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark.

Abstract

Several factors significantly impact ability to produce a sputum sample after an anti-inflammatory intervention and these authors argue that the widely used complete-case analysis is inappropriate for paired sputum-based outcome measures https://bit.ly/3qN2pk5.