Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites

Mohammad Majharul Islam; Iryna Hlushchenko; Simon G Pfisterer

doi:10.3389/fcell.2022.826379

Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites

Front Cell Dev Biol. 2022 Jan 24:10:826379. doi: 10.3389/fcell.2022.826379. eCollection 2022.

Authors

Mohammad Majharul Islam¹, Iryna Hlushchenko¹, Simon G Pfisterer¹

Affiliation

¹ Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Abstract

Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a fundamental process underlying hypercholesterolemia, a high blood cholesterol concentration, affecting more than 40% of the western population. Membrane contact sites influence endosomal dynamics, plasma membrane lipid composition, and cellular cholesterol distribution. However, if we focus on LDL-related trafficking events we mostly discuss them in an isolated fashion, without cellular context. It is our goal to change this perspective and to highlight that all steps from LDL internalization to receptor recycling are likely associated with dynamic membrane contact sites in which endosomes engage with the endoplasmic reticulum and other organelles.

Keywords: endosomal degradation; endosomal recycling; hypercholesterolemia; low-density lipoprotein (LDL); low-density lipoprotein receptor (LDLR); membrane contact site.

Publication types

Review