Successful secukinumab treatment of active bullous pemphigoid and chronic severe psoriasis: a case report

Australas J Dermatol. 2022 May;63(2):e155-e158. doi: 10.1111/ajd.13803. Epub 2022 Feb 9.

Abstract

Since the concurrence of bullous pemphigoid (BP) and psoriasis was first reported in 1929, an increasing number of studies has been published to analyse their relationship in recent years. However, the pathogenesis of the concurrence is not yet well understood, and the coexistence of the two conditions imposes a difficult therapeutic challenge. This case report demonstrates the first case of secukinumab achieving a dramatic clinical improvement of both chronic psoriasis and active BP.

Keywords: bullous pemphigoid; immunobullous; interleukin-17; monoclonal antibody; psoriasis.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Graft vs Host Disease*
  • Humans
  • Pemphigoid, Bullous* / complications
  • Pemphigoid, Bullous* / drug therapy
  • Pemphigoid, Bullous* / pathology
  • Psoriasis* / complications
  • Psoriasis* / drug therapy
  • Psoriasis* / pathology

Substances

  • Antibodies, Monoclonal, Humanized
  • secukinumab