Store-Operated Calcium Entry in the Cardiovascular System

Xian Liu; Zui Pan

doi:10.1007/978-981-16-4254-8_14

Store-Operated Calcium Entry in the Cardiovascular System

Adv Exp Med Biol. 2021:1349:303-333. doi: 10.1007/978-981-16-4254-8_14.

Authors

Xian Liu^{1

2}, Zui Pan^{3

4}

Affiliations

¹ Department of Kinesiology, The University of Texas at Arlington, Arlington, TX, USA.
² Department of Graduate Nursing, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX, USA.
³ Department of Kinesiology, The University of Texas at Arlington, Arlington, TX, USA. zui.pan@uta.edu.
⁴ Department of Graduate Nursing, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX, USA. zui.pan@uta.edu.

PMID: 35138620
DOI: 10.1007/978-981-16-4254-8_14

Abstract

Calcium (Ca²⁺) is a critical regulator of cardiovascular function. The Ca²⁺ channels, pumps, and exchangers contributing to cytosolic Ca²⁺ signals governing cardiac contraction and vascular tone are well known. In addition to these Ca²⁺ components, store-operated calcium entry (SOCE) is a ubiquitous mechanism recently recognized underlying cardiovascular function maintenance and disease development and progression. With this review article, we hope to highlight the accumulated knowledge about the SOCE machinery and its potential contribution to cardiac and vascular function and its roles in cardiovascular pathogenesis and pathology.

Keywords: Calcium signaling; Cardiovascular disease; Orai; SOCE; STIM.

Publication types

Review

MeSH terms

Calcium Channels / metabolism
Calcium Signaling
Calcium* / metabolism
Cardiovascular System* / metabolism
Stromal Interaction Molecule 1 / metabolism

Substances

Calcium Channels
Stromal Interaction Molecule 1
Calcium