Effectiveness of BNT162b2 and mRNA-1273 Second Doses and Boosters for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and SARS-CoV-2-Related Hospitalizations: A Statewide Report From the Minnesota Electronic Health Record Consortium

Paul E Drawz; Malini DeSilva; Peter Bodurtha; Gabriela Vazquez Benitez; Anne Murray; Alanna M Chamberlain; R Adams Dudley; Stephen Waring; Anupam B Kharbanda; Daniel Murphy; Miriam Halstead Muscoplat; Victor Melendez; Karen L Margolis; Lynn McFarling; Roxana Lupu; Tyler N A Winkelman; Steven G Johnson

doi:10.1093/cid/ciac110

Effectiveness of BNT162b2 and mRNA-1273 Second Doses and Boosters for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and SARS-CoV-2-Related Hospitalizations: A Statewide Report From the Minnesota Electronic Health Record Consortium

Clin Infect Dis. 2022 Sep 14;75(5):890-892. doi: 10.1093/cid/ciac110.

Authors

Paul E Drawz¹, Malini DeSilva², Peter Bodurtha³, Gabriela Vazquez Benitez², Anne Murray⁴, Alanna M Chamberlain⁵, R Adams Dudley⁶, Stephen Waring⁷, Anupam B Kharbanda⁸, Daniel Murphy¹, Miriam Halstead Muscoplat⁹, Victor Melendez¹⁰, Karen L Margolis², Lynn McFarling¹¹, Roxana Lupu¹², Tyler N A Winkelman³, Steven G Johnson¹³

Affiliations

¹ Division of Nephrology and Hypertension, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
² HealthPartners Institute, Minneapolis, Minnesota, USA.
³ Health, Homelessness, and Criminal Justice Laboratory, Hennepin Healthcare Research Institute, Minneapolis, Minnesota, USA.
⁴ Berman Center for Clinical Research, Hennepin Healthcare Research Institute, Minneapolis, Minnesota, USA.
⁵ Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
⁶ Center for Care Delivery and Outcomes Research, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA.
⁷ Essentia Institute of Rural Health, Duluth, Minnesota, USA.
⁸ Department of Pediatric Emergency Medicine, Children's Minnesota, Minneapolis, Minnesota, USA.
⁹ Division of Infectious Disease, Epidemiology and Infection Control, Minnesota Department of Health, Saint Paul, Minnesota, USA.
¹⁰ Allina Health, Minneapolis, Minnesota, USA.
¹¹ CentraCare, St Cloud, Minnesota, USA.
¹² Sanford Health, Sioux Falls, South Dakota, USAand.
¹³ Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota, USA.

Abstract

Using vaccine data combined with electronic health records, we report that mRNA boosters provide greater protection than a 2-dose regimen against SARS-CoV-2 infection and related hospitalizations. The benefit of a booster was more evident in the elderly and those with comorbidities.

Keywords: COVID-19; SARS-CoV-2; booster; hospitalization; vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2019-nCoV Vaccine mRNA-1273
Aged
BNT162 Vaccine
COVID-19* / prevention & control
Electronic Health Records
Hospitalization
Humans
Minnesota / epidemiology
RNA, Messenger
SARS-CoV-2* / genetics

Substances

RNA, Messenger
2019-nCoV Vaccine mRNA-1273
BNT162 Vaccine