Warfarin-induced skin necrosis after the use of an anticoagulation reversal agent

Lois Zhang; Kelvin Truong; Linda Chan; Jennifer Kim; Pablo Fernandez-Peñas

doi:10.1111/ajd.13801

Warfarin-induced skin necrosis after the use of an anticoagulation reversal agent

Australas J Dermatol. 2022 May;63(2):e159-e161. doi: 10.1111/ajd.13801. Epub 2022 Feb 8.

Authors

Lois Zhang¹, Kelvin Truong^{1

2}, Linda Chan¹, Jennifer Kim³, Pablo Fernandez-Peñas^{1

2}

Affiliations

¹ Department of Dermatology, Westmead Hospital, Westmead, New South Wales, Australia.
² Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
³ Department of Tissue Pathology and Diagnostic Oncology, Westmead Hospital, Westmead, New South Wales, Australia.

PMID: 35133665
DOI: 10.1111/ajd.13801

Abstract

Anticoagulant-induced skin necrosis is a rare and potentially life-threatening complication of anticoagulant therapy. The majority of cases of anticoagulant-induced skin necrosis have been attributed to warfarin, known as warfarin-induced skin necrosis (WISN). The use of anticoagulation reversal agents such as Prothrombinex-VF in the development of WISN is not a commonly documented phenomenon. The authors present a case of WISN post-recommencement of warfarin and the use of Prothrombinex-VF.

Keywords: anticoagulation reversal; dermatopathology; drug reaction; prothrombinex; warfarin induced skin necrosis.

Publication types

Case Reports

MeSH terms

Anticoagulants / adverse effects
Anticoagulation Reversal
Drug Eruptions* / etiology
Humans
Necrosis / chemically induced
Skin
Soft Tissue Injuries*
Warfarin / adverse effects

Substances

Anticoagulants
Warfarin