Estimation of Effect Heterogeneity in Rare Events Meta-Analysis

Psychometrika. 2022 Sep;87(3):1081-1102. doi: 10.1007/s11336-021-09835-5. Epub 2022 Feb 8.

Abstract

The paper outlines several approaches for dealing with meta-analyses of count outcome data. These counts are the accumulation of occurred events, and these events might be rare, so a special feature of the meta-analysis is dealing with low counts including zero-count studies. Emphasis is put on approaches which are state of the art for count data modelling including mixed log-linear (Poisson) and mixed logistic (binomial) regression as well as nonparametric mixture models for count data of Poisson and binomial type. A simulation study investigates the performance and capability of discrete mixture models in estimating effect heterogeneity. The approaches are exemplified on a meta-analytic case study investigating the acceptance of bibliotherapy.

Keywords: count data analysis; generalised linear mixed models; heterogeneity variance; meta-analysis; nonparametric mixture models; rare events.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Simulation
  • Models, Statistical*
  • Poisson Distribution
  • Psychometrics