A new sesquiterpenoid juvenile hormone III from the stems of Cananga latifolia

Ratchanee Phatchana; Thanaset Senawong; Waranya Lakornwong; Thurdpong Sribuhom; Chavi Yenjai

doi:10.1080/10286020.2022.2030316

A new sesquiterpenoid juvenile hormone III from the stems of Cananga latifolia

J Asian Nat Prod Res. 2022 Dec;24(12):1185-1191. doi: 10.1080/10286020.2022.2030316. Epub 2022 Feb 7.

Authors

Ratchanee Phatchana¹, Thanaset Senawong², Waranya Lakornwong³, Thurdpong Sribuhom³, Chavi Yenjai³

Affiliations

¹ Department of Chemistry, Faculty of Engineering, Rajamangala University of Technology Isan, KhonKaen campus, Khon Kaen 40000, Thailand.
² Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
³ Natural Product Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

PMID: 35130808
DOI: 10.1080/10286020.2022.2030316

Abstract

A new juvenile hormone III, canangalia I (1), along with six known juvenile hormone III analogues (2-7), was isolated from the methanolic extract of Cananga latifolia stems. All structures were elucidated using spectroscopic data and compared with data from previous literature. Canangalia I (1) was found to be cytotoxic against human cervical adenocarcinoma (HeLa) cells with an IC₅₀ value of 35.00 ± 2.15 µg/ml after 72 h, but was not toxic to Vero cells.

Keywords: Annonaceae; Cananga latifolia; cervical adenocarcinoma; cytotoxicity; juvenile hormone III.

MeSH terms

Animals
Cananga* / chemistry
Chlorocebus aethiops
Humans
Molecular Structure
Sesquiterpenes* / chemistry
Vero Cells

Substances

juvenile hormone III
Sesquiterpenes