Exophiala dermatitidis, 'the real black fungus' fungemia in a patient with COVID-19

Mohd Nizam Tzar; Wan Husna Barakah Meor Jamaludin; Asrul Abdul Wahab; Chuan Hun Ding

doi:10.1016/j.idcr.2022.e01428

Exophiala dermatitidis, 'the real black fungus' fungemia in a patient with COVID-19

IDCases. 2022:27:e01428. doi: 10.1016/j.idcr.2022.e01428. Epub 2022 Jan 29.

Authors

Mohd Nizam Tzar¹, Wan Husna Barakah Meor Jamaludin¹, Asrul Abdul Wahab¹, Chuan Hun Ding¹

Affiliation

¹ Department of Medical Microbiology and Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia.

Abstract

The second wave of the COVID-19 pandemic in India had brought with it a surge of 'black fungus' co-infection, which is a misnomer for mucormycosis. The present case illustrates the 'real black fungus' infection in a 50-year old male patient with COVID-19 pneumonia, who otherwise had no significant previous medical history. He was admitted on day 8 of COVID-19 illness and was intubated due to persistently low oxygen saturation. Blood cultures were positive for flask-shaped dematiaceous budding yeasts with pseudohyphae formation, which grew as brown-black fuzzy colonies on Sabouraud dextrose agar. The isolate was identified as Exophiala dermatitidis based on phenotypic characterization. Despite antifungal therapy with amphotericin B and itraconazole, the patient deteriorated rapidly and succumbed to acute respiratory distress syndrome and multiorgan failure. A review of reported cases of Exophiala dermatitidis fungemia over the last 5-years is discussed.

Keywords: Antifungal; COVID-19; Coronavirus; Dematiaceous; Malaysia; Mycosis.

Publication types

Case Reports