How is insulin-like growth factor-1 correlated with retinopathy of prematurity?

Nahid Jafari; Arezoo Karimi Moghadam; Naeeme Taslimi Taleghani; Neda Hosseini Nezhad; Nima Motamed; Ahmad Jalilvand

doi:10.4103/jrms.JRMS_501_20

How is insulin-like growth factor-1 correlated with retinopathy of prematurity?

J Res Med Sci. 2021 Nov 29:26:111. doi: 10.4103/jrms.JRMS_501_20. eCollection 2021.

Authors

Nahid Jafari¹, Arezoo Karimi Moghadam², Naeeme Taslimi Taleghani³, Neda Hosseini Nezhad⁴, Nima Motamed⁵, Ahmad Jalilvand⁶

Affiliations

¹ Department of Neonatology and Perinatology, Zanjan University of Medical Science, Zanjan, Iran.
² Retin Specialist, Zanjan University of Medical Science, Zanjan, Iran.
³ Neonatal Health Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Department of Pediatrics, Zanjan University of Medical Science, Zanjan, Iran.
⁵ Statistics and Epidemiology, Department of Social Medicine, Medical School, Zanjan university of Medical Science, Zanjan, Iran.
⁶ Department of Pathology, Zanjan University of Medical Science, Zanjan, Iran.

Abstract

Background: Evaluation of insulin-like growth factor-1 (IGF-1) association with retinopathy of prematurity (ROP) is our object.

Materials and methods: This study was conducted on IGF-1 levels of 40 neonates <34 weeks gestational age and 2000 g at 1^st week and 4-6 weeks after birth. All participants were evaluated for ROP after 31 weeks of gestation.

Results: IGF-1 levels showed a significant difference between neonates ≤1500 and 1500-2000 g (1 and 4-6 weeks, P = 0.008, P = 0.039, respectively). No significant association was found between IGF-1 and ROP.

Conclusion: Finding a meaningful association between IGF-1 and ROP requires consideration of factors affecting the IGF-1.

Keywords: Insulin-like growth factor-1; preterm birth; retinopathy of prematurity.