Serum Gastrin and Pepsinogen Levels after Administration of Acid Secretion Inhibitors for Ulcers due to Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer

Maidina Abuduwaili; Tomoyuki Boda; Masanori Ito; Hidehiko Takigawa; Takahiro Kotachi; Taiji Matsuo; Shiro Oka; Shinji Tanaka

doi:10.1155/2022/2830227

Serum Gastrin and Pepsinogen Levels after Administration of Acid Secretion Inhibitors for Ulcers due to Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer

Gastroenterol Res Pract. 2022 Jan 28:2022:2830227. doi: 10.1155/2022/2830227. eCollection 2022.

Authors

Maidina Abuduwaili¹, Tomoyuki Boda¹, Masanori Ito², Hidehiko Takigawa¹, Takahiro Kotachi¹, Taiji Matsuo¹, Shiro Oka³, Shinji Tanaka¹

Affiliations

¹ Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
² Department of General Internal Medicine, Hiroshima University Hospital, Hiroshima, Japan.
³ Department of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan.

Abstract

Acid secretion inhibitors, such as proton pump inhibitors (PPIs) and potassium competitive acid blockers (PCABs), are used to treat ulcers after endoscopic submucosal dissection (ESD) for early gastric cancer. These drugs can influence serum gastrin and pepsinogen (PG) levels; however, their definite effects remain unclear. This open-label, randomized study investigated the effect of acid secretion inhibitors on the serum gastrin and pepsinogen levels. In total, 76 patients were enrolled in the study. They underwent gastric ESD and received a PPI (n = 21) or PCAB (n = 55). Changes in the serum gastrin and PG levels before and 4 weeks after administration were examined. Patient factors associated with the alteration of serum PG or gastrin levels were identified. The median serum levels of gastrin, PGI, and PGII before the administration of the acid secretion inhibitors were 110.5 pg/mL, 36.4 ng/mL, and 8.9 ng/mL, respectively; after administration, the levels increased to 300 pg/mL, 64.7 ng/mL, and 15.8 ng/mL, respectively (P < 0.01). Univariate analysis revealed that PCABs led to a more significant increase in the serum gastrin and PG levels as compared to PPIs. Furthermore, the PG levels were significantly increased in patients with previous Helicobacter pylori infections than in those with current infections. In conclusion, the serum gastrin and PG levels increased after the use of acid secretion inhibitors. This elevation was affected by the type of drug used, whereas the elevation in PGs was affected by the patient's background as well.