Acute Promyelocytic Leukemia with t(2;3): An Unusual Additional Chromosomal Abnormality

Smeeta Gajendra; Anil Kumar Yadav; Manorama Bhargava

doi:10.1007/s12288-021-01468-z

Acute Promyelocytic Leukemia with t(2;3): An Unusual Additional Chromosomal Abnormality

Indian J Hematol Blood Transfus. 2022 Jan;38(1):202-203. doi: 10.1007/s12288-021-01468-z. Epub 2021 Jul 10.

Authors

Smeeta Gajendra¹, Anil Kumar Yadav², Manorama Bhargava³

Affiliations

¹ Laboratory Oncology Unit, Dr BRAIRCH, All India Institute of Medical Sciences, New Delhi, 110029 India.
² Cancer Cytogenetics Department, HBCH & MPMMMCH, Varanashi, India.
³ Department of Hematopathology, Medanta - The Medicity Hospital, Sector 38, Gurgaon, 122001 India.

Abstract

Acute promyelocytic leukemia is a distinct subset of acute myeloid leukemia with characteristic clinical, morphological and genetic features. The gene product PML-RAR alpha resulting from reciprocal t(15;17) translocation, plays a pivotal role in the pathogenesis of acute promyelocytic leukemia and classified as favorable cytogenetic features. We are describing an unusual additional chromosomal abnormality t(2;3) in APL patient.

Keywords: Acute promyelocytic leukemia; Additional chromosomal abnormality; Karyotype; t(2;3).