Pharmaceuticals are globally consumed by humans and animals to support daily health and to treat disease. Following consumption, they may reach the aquatic environment either directly through the discharge of untreated wastewater to water bodies, or indirectly via treated wastewater as a result of their incomplete removal from wastewater treatment plants. This paper reviews the processes that control the occurrence and fate of pharmaceuticals in water systems, including sorption, photodegradation, hydrolysis and biodegradation. The degree to which these four processes occur is influenced by pharmaceutical types and their chemical structure as well as environmental factors such as sunlight, water depth, organic matter content, water chemistry, sediment properties, and type and abundance of microorganisms. Depending on the complex interactions of these factors, pharmaceutical compounds may be mineralized, partially degraded, or remain intact because they are resistant to degradation. Kinetic rate parameters and the half-life of a variety of pharmaceutical products are provided herein for the above processes under different environmental conditions. Usually, photodegradation and biodegradation represent dominant reaction processes, while hydrolysis only affects some pharmaceuticals, particularly antibiotics. The identified sorption and reaction rate parameters can be incorporated into a concise modeling framework to assess and predict longitudinal concentration profiles of pharmaceutical products in the manmade and natural systems, particularly when large amounts of pharmaceuticals are discharged during abnormal events such as a virus outbreak. Finally, future research is suggested, including the fate of transformed products (intermediates) in water systems.
Keywords: Mathematical model; Pharmaceuticals; Reaction rate; Transport and fate; Water system.
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