Objective: To investigate the clinical features of acute myeloid leukemia patients with hemophagocytic syndrome.
Methods: The clinical data of 2 patients with acute myeloid leukemia complicated with hemophagocytic syndrome were collected, and the clinical characteristics and treatment outcomes were analyzed.
Results: There were two patients with acute myeloid leukemia, including 1 male and 1 female，aged for 67 and 40 years old，respectively. Hemophagocytic syndrome occurred in one patient after induction therapy for acute myeloid leukemia and one patient after consolidation therapy. Both of the patients with hemophagocytic syndrome showed fever, hemocytopenia, high ferritin, high titer sCD25 levels and hemophagocytes in bone marrow. After achieved anti-infection, glucocorticoid, human immunoglobulin and etoposide regimens treatment, hemophagocytic syndrome was controlled in both of the two patients. One patient failed to induce acute myeloid leukemia and one patient achieved complete remission.
Conclusion: Acute myeloid leukemia complicated with hemophagocytic syndrome is rare. Early identification, early anti-infection combined with HLH94 regimen can control hemophagocytosis and improve prognosis.
题目: 急性髓系白血病合并噬血细胞综合征患者的临床分析.
目的: 探讨急性髓系白血病合并噬血细胞综合征患者的临床特征.
方法: 收集2例急性髓系白血病合并噬血细胞综合征患者的临床资料，分析其临床特征、治疗转归.
结果: 2例急性髓系白血病患者，其中男性1例，女性1例，年龄分别为67和40岁。1例患者噬血细胞综合征发生在急性髓系白血病诱导治疗后，另1例患者发生在巩固治疗后。2例患者发生噬血细胞综合征时均有发热、血细胞减少、铁蛋白高、高滴度sCD25水平及骨髓见噬血细胞。经积极抗感染、糖皮质激素、人免疫球蛋白和依托泊苷方案治疗，2例患者噬血细胞综合征得到控制，其中1例患者急性髓系白血病诱导失败，1例患者急性髓系白血病获得持续完全缓解.
结论: 急性髓系白血病合并噬血细胞综合征临床少见，应早期识别，早期抗感染联合HLH94方案治疗，控制噬血，改善患者预后.
Keywords: acute myeloid leukemia; clinical characteristic; hemophagocytic syndrome; prognosis.