CCAAT enhancer binding protein gamma (C/EBP-γ): An understudied transcription factor

Adv Biol Regul. 2022 May:84:100861. doi: 10.1016/j.jbior.2022.100861. Epub 2022 Jan 26.

Abstract

The CCAAT enhancer binding protein (C/EBP) family of transcription factors are important transcriptional mediators of a wide range of physiologic processes. C/EBP-γ is the shortest C/EBP protein and lacks a canonical activation domain for the recruitment of transcriptional machinery. Despite its ubiquitous expression and ability to dimerize with other C/EBP proteins, C/EBP-γ has been studied far less than other C/EBP proteins, and, to our knowledge, no review of its functions has been written. This review seeks to integrate the current knowledge about C/EBP-γ and its physiologic roles, especially in cell proliferation, the integrated stress response, oncogenesis, hematopoietic and nervous system development, and metabolism, as well as to identify areas for future research.

Keywords: CCAAT-Enhancer binding protein; Cancer; Cell proliferation; Integrated stress response; Neuronal development; Transcription factor.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • CCAAT-Enhancer-Binding Proteins / genetics
  • CCAAT-Enhancer-Binding Proteins / metabolism
  • Gene Expression Regulation
  • Humans
  • Promoter Regions, Genetic
  • Protein Binding
  • Transcription Factors* / metabolism
  • Transcription, Genetic*

Substances

  • CCAAT-Enhancer-Binding Proteins
  • Transcription Factors