Anti-tumor alkaloids from Peganum harmala

Qin Zhang; Yan-Hui Zan; Han-Gao Yang; Meng-Yue Yang; Fang-Shen Liu; Sheng-Ge Li; Xiao-Hui Peng; Bin Lin; Zhan-Lin Li; Da-Hong Li; Hui-Ming Hua

doi:10.1016/j.phytochem.2022.113107

Anti-tumor alkaloids from Peganum harmala

Phytochemistry. 2022 May:197:113107. doi: 10.1016/j.phytochem.2022.113107. Epub 2022 Feb 1.

Authors

Affiliations

¹ Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
² School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning Province, PR China.
³ Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: lidahong0203@163.com.
⁴ Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: huimhua@163.com.

PMID: 35121215
DOI: 10.1016/j.phytochem.2022.113107

Abstract

Six alkaloids peharmalines F-K, along with 14 known ones, were isolated from the aerial part of Peganum harmala L.. The structures of the isolated compounds were determined based on their HR-ESI-MS data, extensive NMR spectroscopic analyses, and ECD calculations. 3-(4-Hydroxyphenyl)quinoline exhibited potent antiproliferative activity against the HepG-2 cell lines with an IC₅₀ value of 3.05 μM. Norharmane displayed a moderate inhibition against A549 and HepG-2 cells with IC₅₀ values of 16.45 μM and 17.27 μM, respectively.

Keywords: Alkaloids; Anti-tumor; Peganum harmala L.; The aerial part; Zygophyllaceae.

MeSH terms

A549 Cells
Alkaloids* / chemistry
Antineoplastic Agents, Phytogenic* / chemistry
Hep G2 Cells
Humans
Peganum* / chemistry
Plant Extracts / chemistry

Substances

Alkaloids
Antineoplastic Agents, Phytogenic
Plant Extracts