Quickly moving too slowly: Interneuron migration in Timothy Syndrome

Michael B Fernando; Kristen J Brennand

doi:10.1016/j.stem.2022.01.004

Quickly moving too slowly: Interneuron migration in Timothy Syndrome

Cell Stem Cell. 2022 Feb 3;29(2):181-183. doi: 10.1016/j.stem.2022.01.004.

Authors

Michael B Fernando¹, Kristen J Brennand²

Affiliations

¹ Graduate School of Biomedical Science, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Nash Family Department of Neuroscience, Friedman Brain Institute, Pamela Sklar Division of Psychiatric Genomics, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
² Nash Family Department of Neuroscience, Friedman Brain Institute, Pamela Sklar Division of Psychiatric Genomics, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address: kristen.brennand@yale.edu.

PMID: 35120616
DOI: 10.1016/j.stem.2022.01.004

Abstract

Aberrant migration of GABAergic interneurons during cortical neurodevelopment is implicated in Timothy Syndrome, yet the underlying mechanisms remain elusive. In this issue of Cell Stem Cell, Birey et al. model developing brain circuitry using "assembloids" from patients, characterizing a bimodal mechanism of mechano-chemically driven interneuron migration inefficiencies.

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Comment

MeSH terms

Autistic Disorder*
Humans
Interneurons / physiology
Long QT Syndrome*
Syndactyly* / genetics

Supplementary concepts

Timothy syndrome