Multifaceted Engineered Biomimetic Nanorobots Toward Cancer Management

ACS Biomater Sci Eng. 2022 Feb 14;8(2):444-459. doi: 10.1021/acsbiomaterials.1c01352. Epub 2022 Feb 4.

Abstract

The noteworthy beneficiary to date in nanotechnology is cancer management. Nanorobots are developed as the result of advancements in the nanostructure, robotics, healthcare, and computer systems. These devices at the nanoscale level are beneficial in the prevention, diagnosis, and treatment of various health conditions notably cancer. Though these structures have distinct potentialities, the usage of inorganic substances in their construction can affect their performance and can cause health issues in the body. To overcome this, naturally inspired substances are incorporated in the fabrication process of nanorobots termed biomimetic nanorobots that can overcome the immunological responses and reduce the side effects with effective functionalization. These biomimetic nanorobots can widen the opportunities in cancer imaging and therapy. Herein, an up-to-date review of biomimetic nanorobots along with their applications in cancer management is provided. Furthermore, the safety issues and future directions of biomimetic nanorobots to achieve clinical translation are also stated.

Keywords: biomimetic; cancer; cancer imaging; cancer therapy; nanorobots; nanotechnology.

MeSH terms

  • Biomimetics
  • Humans
  • Nanostructures* / therapeutic use
  • Nanotechnology
  • Neoplasms* / therapy
  • Robotics*