Identification of Five Ferroptosis-Related LncRNAs as Novel Prognosis and Diagnosis Signatures for Renal Cancer

Xiangjun Shu; Zaiqi Zhang; Zhi-Yong Yao; Xiao-Liang Xing

doi:10.3389/fmolb.2021.763697

Identification of Five Ferroptosis-Related LncRNAs as Novel Prognosis and Diagnosis Signatures for Renal Cancer

Front Mol Biosci. 2022 Jan 18:8:763697. doi: 10.3389/fmolb.2021.763697. eCollection 2021.

Authors

Xiangjun Shu^{1

2}, Zaiqi Zhang², Zhi-Yong Yao², Xiao-Liang Xing^{1

2}

Affiliations

¹ School of Public Health and Laboratory Medicine, Hunan University of Medicine, Huaihua, China.
² The First Affiliated Hospital, Hunan University of Medicine, Huaihua, China.

Abstract

Background: Ferroptosis is a novel regulated cell death that is characterized by iron-dependent oxidative damage. Renal cancer is the second most common cancer of the urinary system, which is highly correlated with iron metabolism. The aim of our present study was to identify suitable ferroptosis-related prognosis signatures for renal cancer. Methods: We downloaded the RNA-seq count data of renal cancer from The Cancer Genome Atlas database and used the DESeq2, Survival, and Cox regression analyses to screen the prognosis signatures. Results: We identified 5 ferroptosis-related differentially expressed lncRNAs (FR-DELs) (DOCK8-AS1, SNHG17, RUSC1-AS1, LINC02609, and LUCAT1) to be independently correlated with the overall survival (OS) of patients with renal cancer. The risk assessment model and diagnosis model constructed by those 5 FR-DELs could well predict the outcome and the diagnosis of renal cancer. Conclusion: Our present study not only suggested those 5 FR-DELs could be used as prognosis and diagnosis signatures for renal cancer but also provided strategies for other cancers in the screening of ferroptosis-related biomarkers.

Keywords: diagnosis; differentially expressed lncRNAs; ferroptosis; prognosis; renal cancer.