Background: Lymph node status has a strong predictive effect on the prognosis of all patients with gastric cancer. It is unclear whether the positive lymph node ratio (PLNR) is a reliable prognostic factor for gastric signet ring cell carcinoma (SRCC).
Methods: Patients with SRCC were obtained from the Surveillance, Epidemiology and End Results (SEER) database for the years 1998-2013. Cutoff values of positive lymph node ratio (PLNR) were decided using X-tile program. Survival was determined using the Kaplan-Meier method. Univariate and multivariate analyses were used to identify prognosticator of gastric signet ring cell carcinoma.
Results: A total of 1,884 cases were identified. 0.8 as the optimal cutoff value to separate the patients into high and low risk subsets in accordance of cancer-caused survival in SRCC patients (the number as 0.8, P<0.0001). Patients with PLNR >0.8 remained to have a poorer prognosis compared with those with PLNR <0.8 as shown by both OS (HR =2.083, 95% CI: 1.862-2.33, P<0.001) and CSS (HR =2.052, 95% CI: 1.802-2.336, P=0.014) in the multivariate cox regression model.
Conclusions: PLNR is of great significance in the evaluation of prognosis for patients with SRCC.
Keywords: Lymph node ratio; SEER program; gastric cancer; signet ring cell carcinoma.
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