Rudimentary methods for electronic waste (e-waste) recycling employed in developing countries are a source of work-related musculoskeletal disorders (WRMSDs). A summarized comparison of WRMSDs and preliminary exposure assessment among e-waste dismantlers (D) and burners (B) in Agbogbloshie, Ghana is presented. A cross-sectional study was conducted to investigate WRMSDs and associated risk factors using the Cornell Musculoskeletal Discomfort Questionnaire and a newly developed ergonomic assessment tool. Results indicated higher WRMSDs prevalence in the lower back (68% D vs. 52% B; p = 0.172), shoulder (41% D vs. 29% B; p = 0.279) and upper arm (33% D vs 5% B; p = 0.010). Moderate to severe trunk flexion, high force exertion, repetition and vibration were prevalent risk factors among workers and were significantly higher in dismantlers than burners (p ≤ 0.001). Detailed ergonomic studies investigating the relationship between physical exposures and WRMSDs are needed to provide a deeper understanding of WRMSD causation in e-waste workers and more particularly in unstructured, unregulated work.