Lethal mutagenesis as an antiviral strategy

Science. 2022 Feb 4;375(6580):497-498. doi: 10.1126/science.abn0048. Epub 2022 Feb 3.

Abstract

[Figure: see text].

MeSH terms

  • Animals
  • Antiviral Agents / adverse effects
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • COVID-19 / virology
  • COVID-19 Drug Treatment
  • Cytidine / adverse effects
  • Cytidine / analogs & derivatives*
  • Cytidine / metabolism
  • Cytidine / pharmacology
  • Cytidine / therapeutic use
  • Cytidine / toxicity
  • DNA / biosynthesis
  • Evolution, Molecular
  • Genome, Viral
  • Humans
  • Hydroxylamines / adverse effects
  • Hydroxylamines / metabolism
  • Hydroxylamines / pharmacology*
  • Hydroxylamines / therapeutic use
  • Mutagenesis*
  • Mutagenicity Tests
  • Phosphorylation
  • RNA Virus Infections / drug therapy
  • RNA Virus Infections / virology
  • RNA Viruses / drug effects*
  • RNA Viruses / genetics
  • RNA, Viral / biosynthesis
  • RNA, Viral / genetics
  • Ribonucleosides / metabolism
  • SARS-CoV-2 / drug effects*
  • SARS-CoV-2 / genetics

Substances

  • Antiviral Agents
  • Hydroxylamines
  • RNA, Viral
  • Ribonucleosides
  • Cytidine
  • DNA
  • N(4)-hydroxycytidine
  • molnupiravir