We report a visible-light-induced three-component sulfonyl-heteroarylation of vinyl ethers with sulfinates and five-membered heteroaryl chlorides. This protocol proceeds via electron-donor-acceptor (EDA) complexes between sulfinates and heteroaryl chlorides, giving β-sulfonyl alkyl five-membered heteroarenes with high efficiency and excellent regioselectivity under mild and catalyst-free conditions. Utilization of CF3 SO2 Na or CF2 HSO2 Na as coupling partners further achieves three-component fluoromethyl-arylation of vinyl ethers, furnishing a series of valuable CF3 /CF2 H-incorporated alkyl heterocycles under mild conditions.
Keywords: alkenes; catalyst-free reactions; difunctionalization; electron-donor-acceptor complex; radical cascade.
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