PrACTiC: A Predictive Algorithm for Chemoradiotherapy-Induced Cytopenia in Glioblastoma Patients

Alireza Amouheidari; Zahra Alirezaei; Stefan Rauh; Masoud Hassanpour

doi:10.1155/2022/1438190

PrACTiC: A Predictive Algorithm for Chemoradiotherapy-Induced Cytopenia in Glioblastoma Patients

J Oncol. 2022 Jan 24:2022:1438190. doi: 10.1155/2022/1438190. eCollection 2022.

Authors

Alireza Amouheidari¹, Zahra Alirezaei², Stefan Rauh³, Masoud Hassanpour⁴

Affiliations

¹ Department of Oncology, Isfahan Milad Hospital, Isfahan, Iran.
² Paramedical School, Bushehr University of Medical Sciences, Bushehr, Iran.
³ Department of Medical Oncology, Centre Hospitalier Emile Mayrisch, Esch, Luxembourg.
⁴ Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences (RCMCI), Tehran, Iran.

Abstract

Background: Chemotherapy-induced cytopenia is the most frequent side effect of chemoradiotherapy in glioblastoma patients which may lead to reduced delivery of treatment. This study aims to develop a predictive model that is able to forecast the cytopenia induced by temozolomide (TMZ) during concomitant chemoradiotherapy.

Methods: Medical records of 128 patients with newly diagnosed glioblastoma were evaluated to extract the baseline complete blood test before and during the six weeks of chemoradiotherapy to create a dataset for the development of ML models. Using the constructed dataset, different ML algorithms were trained and tested.

Results: Our proposed algorithm achieved accuracies of 85.6%, 88.7%, and 89.3% in predicting thrombocytopenia, lymphopenia, and neutropenia, respectively.

Conclusions: The algorithm designed and developed in this study, called PrACTiC, showed promising results in the accurate prediction of thrombocytopenia, neutropenia, and lymphopenia induced by TMZ in glioblastoma patients. PrACTiC can provide valuable insight for physicians and help them to make the necessary treatment modifications and prevent the toxicities.