Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model

Rohmad Yudi Utomo; Atsushi Sugie; Satoshi Okada; Kazuki Miura; Hiroyuki Nakamura

doi:10.1039/d1cc07000b

Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model

Chem Commun (Camb). 2022 Feb 17;58(15):2576-2579. doi: 10.1039/d1cc07000b.

Authors

Rohmad Yudi Utomo¹, Atsushi Sugie², Satoshi Okada^{1

3

4}, Kazuki Miura^{1

3}, Hiroyuki Nakamura^{1

3}

Affiliations

¹ School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan. hiro@res.titech.ac.jp.
² Brain Research Institute, Niigata University, 757, Ichiban-cho, Asahimachidori, Chuo-ku, Niigata 951-8585, Japan. atsushi.sugie@bri.niigata-u.ac.jp.
³ Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan.
⁴ JST, PRESTO, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan.

PMID: 35107458
DOI: 10.1039/d1cc07000b

Abstract

Curcumin derivatives B and N were developed as disaggregation agents of amyloid β (Aβ) fibrils. The detoxification provided by each compound at a concentration of 1 μM was observed in neuroblastoma cells. Furthermore, both compounds significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease.

MeSH terms

Alzheimer Disease / drug therapy*
Alzheimer Disease / metabolism
Amyloid beta-Peptides / antagonists & inhibitors*
Amyloid beta-Peptides / metabolism
Animals
Curcumin / chemistry
Curcumin / pharmacology*
Disease Models, Animal*
Dose-Response Relationship, Drug
Drosophila
Molecular Structure

Substances

Amyloid beta-Peptides
Curcumin