Myocarditis following rAd26 and rAd5 vector-based COVID-19 vaccine: case report

Farah Naghashzadeh; Shadi Shafaghi; Atosa Dorudinia; Seyed Alireza Naji; Majid Marjani; Ahmad Amin; Arezoo Mohamadifar; Sima Noorali; Babak Sharif Kashani

doi:10.1002/ehf2.13821

Myocarditis following rAd26 and rAd5 vector-based COVID-19 vaccine: case report

ESC Heart Fail. 2022 Apr;9(2):1483-1486. doi: 10.1002/ehf2.13821. Epub 2022 Feb 1.

Authors

Farah Naghashzadeh¹, Shadi Shafaghi¹, Atosa Dorudinia², Seyed Alireza Naji³, Majid Marjani⁴, Ahmad Amin⁵, Arezoo Mohamadifar², Sima Noorali¹, Babak Sharif Kashani^{1

6}

Affiliations

¹ Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Dr. Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁵ Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
⁶ Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

SARS-CoV-2 vaccines provide a safe solution with a major impact on reducing the spread of the virus and mild side effects. Research has shown rare cases of myocarditis after mRNA vaccines. This study presents a 29-year-old male with chest pain after 48 h of receiving rAd26 and rAd5 vector-based COVID-19 vaccine (Sputnik V vaccine). The electrocardiogram revealed ST-segment elevation. Also, the laboratory screening was remarkable for elevated cardiac Troponin-I level, and leukocytosis; and echocardiography depicted severe left ventricular systolic dysfunction. Overall, endomyocardial biopsy proved lymphocytic myocarditis such that the patient was successfully treated with immunosuppressive and guideline-directed medical treatment.

Keywords: Cardiovascular; Complication; Gam-COVID-Vac; SARS-CoV-2; Sputnik V vaccine.

Publication types

Case Reports

MeSH terms

Adult
COVID-19 Vaccines / adverse effects
COVID-19*
Heart
Humans
Male
Myocarditis* / diagnosis
Myocarditis* / etiology
SARS-CoV-2

Substances

COVID-19 Vaccines