Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages

Signal Transduct Target Ther. 2022 Feb 2;7(1):34. doi: 10.1038/s41392-021-00807-w.

Yuxin Shu^#^{1

2}, Nanfei Yang^#¹, Nan Cheng^#¹, Zhengyun Zou¹, Wenlong Zhang¹, Yuncheng Bei¹, Qian Shi³, Menghao Qin¹, Wei-Guo Zhu⁴, Pingping Shen^{5

6}

¹ State Key Laboratory of Pharmaceutical Biotechnology and The Comprehensive Cancer Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210023, PR China.
² Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University International Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University, Shenzhen, 518060, PR China.
³ Department of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3904, USA.
⁴ Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University International Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University, Shenzhen, 518060, PR China. zhuweiguo@szu.edu.cn.
⁵ State Key Laboratory of Pharmaceutical Biotechnology and The Comprehensive Cancer Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210023, PR China. ppshen@nju.edu.cn.
⁶ Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University International Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University, Shenzhen, 518060, PR China. ppshen@nju.edu.cn.

^# Contributed equally.

No abstract available

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